Alnylam Pharmaceuticals Announces Initiation of APOLLO-B Phase 3 Study of Patisiran for the Treatment of Transthyretin Amyloidosis with Cardiomyopathy

Alnylam Pharmaceuticals Announces Initiation of APOLLO-B Phase 3 Study of Patisiran for the Treatment of Transthyretin Amyloidosis with Cardiomyopathy

“ATTR is rare, life-threatening disease encompassing hereditary (hATTR) wild-type (wtATTR) amyloidosis. Based encouraging exploratory results cardiac endpoints APOLLO study,” said Green, TTR Program. initiation APOLLO-B represents significant milestone our explore full patisiran for patients all types amyloidosis. ” Patisiran is drug name for ONPATTRO®. It is approved by U. S. Food Drug Administration (FDA) for treatment polyneuropathy hATTR adults. ONPATTRO is also approved European Union, APOLLO-B Study The APOLLO-B trial is randomized, multicenter global study designed evaluate efficacy patisiran approximately adult patients (hereditary Alnylam Pharmaceuticals Announces or wild type) cardiomyopathy.

Transthyretin amyloid cardiomyopathy is a rare inherited and slowly progressive cardiac disease, in which a protein-based infiltrate deposits in tissues as beta-pleated sheets. The disease is characterized by an abnormal buildup of deposits of a mutant and wild-type transthyretin (TTR) protein in the heart called TTR amyloid fibrils in the body's organs and tissues. This leads to diastolic dysfunction from restrictive cardiomyopathy and eventual heart failure. In amyloid heart disease the U. S. , the most common mutation (V122I) is seen predominantly among individuals of African descent.  There are three types of transthyretin amyloid cardiomyopathy: light-chain amyloidosis, mutant transthyretin amyloidosis, and wild-type transthyretin amyloidosis. All three forms of transthyretin amyloid cardiomyopathy are progressive and fatal. For patients with wild-type transthyretin amyloidosis cardiomyopathy and mutant transthyretin amyloidosis cardiomyopathy, symptoms usually manifest later in life (after the age of 50).

September 9, the American Heart (AHA), the European ASNC Announces Multisocietal Nuclear (EANM), the Society Amyloidosis (ISA), the Society Nuclear Transthyretin Amyloid Cardiomyopathy Molecular Imaging (SNMMI). Emerging imaging methods have earlier diagnosis improved prognostication with new treatment options. The diagnostic criteria for.

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